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Scientist/Sr. Scientist, Bioassay. Job in South San Francisco FOX8 Jobs

Location
South San Francisco, California
Job Type
Permanent
Posted
10 Jun 2022

About Us:

Vaxart is a clinical-stage biotechnology company developing a range of oral recombinant vaccines based on its proprietary delivery platform. Vaxart vaccines are administered using convenient room temperature-stable tablets that can be stored and shipped without refrigeration.

Vaxart has demonstrated that its proprietary tablet vaccine delivery platform is suitable to deliver recombinant vaccines, positioning the company to develop oral versions of currently marketed vaccines and to design recombinant vaccines for new indications. Its development programs currently include tablet vaccines designed to protect against coronavirus, norovirus, seasonal influenza and respiratory syncytial virus (RSV), as well as a therapeutic vaccine for human papillomavirus (HPV), Vaxart's first immuno-oncology indication.

Our mission is the promotion of global health through the development of effective vaccines that can be administered by tablet rather than by injection, providing for the simple and efficient distribution and administration of safe vaccines in any setting.

Summary

The Senior Scientist will design, develop and qualify analytical methods for biopotency and viral vector characterization for development and manufacture of recombinant Ad5 vectors used for oral vaccines. Experience with cell-based assays such as infectivity, transgene expression and potency determination is strongly preferred. Support existing methods and development of new methods appropriate for product and process characterization, release testing, and for in-process testing of product and intermediates.

Multiple positions are available.

Responsibilities:

  • Independently designs, develops and optimizes cell-based assays such as infectivity, transgene expression, and biopotency assays to support product development and characterization.
  • Performs DOE studies to establish assay acceptance criteria to support method validation and product specifications applying appropriate statistical tools to comply with regulatory guidelines.
  • Evaluates new assay technologies and innovates novel assay methodologies.
  • Authors and reviews protocols, development reports, standard operating procedures, and other technical reports.
  • Responsible for understanding and applying data generated from experiments and literature to support process development activities.
  • Supports and trains staff as appropriate in laboratory activities. Assures that training and compliance records for themselves are up to date and appropriate.
  • Proactively communicates with internal and external stakeholders and supervisor, as well as peers.

Requirements:

  • PhD degree in Cell biology, Biochemistry, or related disciplines with 8+ years of experience, preferably in biotech or pharma industry with primary focus on biologics.
  • Knowledge of FDA, cGMP, and ICH regulatory requirements in the context of bioassay/potency assay development and qualification is desired.
  • Experience with method validation and transfer to in-house QC is required.
  • Good understanding of statistical methods/tools for data analysis is required.
  • Experience with Mammalian cell culture and production of viral vectors is a strong plus.
  • Team player, good interpersonal and organizational skills.
  • Excellent written and oral communication skills is required.

Vaccination Requirement:

Vaxart has implemented a mandatory COVID-19 vaccination policy which requires our employees to be fully vaccinated against COVID as a condition of employment. Vaxart will make reasonable accommodations for valid exemptions based on disability, medical, or religious reasons. Vaxart prioritizes sound science and available facts to best ensure the ongoing safety of our employees and the community.

Vaxart offers team members a competitive compensation and benefits package, including a robust health plan, bonus program, stock options, 401K with employer matching, tuition assistance, and work-life balance.

Vaxart is an Equal Opportunity Employer and values diversity. We are committed to the principles of equal employment opportunity and affirmative action for all applicants and employees. Equal opportunity and consideration are afforded to all qualified applicants and employees in personnel actions, which include recruiting and hiring, selection for training, promotion, rates of pay or other compensation, transfer, discipline, demotion, and layoff or termination. Vaxart does not unlawfully discriminate on the basis of race, color, religion, sexual orientation, marital status, pregnancy, gender identity, gender expression, family medical history or genetic information, citizenship, national origin or ancestry, sex, age, physical or mental disability, medical condition, veteran status, military status, or any other basis protected by federal, state or local law, ordinance or regulation.

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Details

  • Job Reference: 620992389-2
  • Date Posted: 10 June 2022
  • Recruiter: Vaxart, Inc.
  • Location: South San Francisco, California
  • Salary: On Application
  • Sector: Science & Technology
  • Job Type: Permanent